Our Previous Drug & Vaccine Discovery Applications

Useful Links and References 

Useful Links:

Coming Soon…

Description:  “COVID-19 Healthcare Coalition, resource sharing dashboard”
link: https://c19hcc.org/

 

Description: “Nextstrain, Genetic Epidemiology of coronavirus”
link: https://nextstrain.org/ncov/global

 

Description: “UC Riverside article describing nsp10/16 complex is a potential target of antiviral drugs”
link: https://news.ucr.edu/articles/2020/03/20/new-drug-target-found-covid-19

 

Description: “New York Times article describing malaria drug hydroxychloroquine relief symptoms of coronavirus”
link: https://www.nytimes.com/2020/04/01/health/hydroxychloroquine-coronavirus-malaria.html

 

Description:  “Hotspot prediction between ACE2 and S protein receptor binding domain and between nsp10/16”
link: https://drive.google.com/drive/u/1/folders/1Lnt-rrFSBOLnDYHhPduCv7eS4cQ9YqEX

 

Description:  “Thorn lab revised crystal structures of viral proteins”
link: https://github.com/thorn-lab/coronavirus_structural_task_force/tree/master/pdb

 

Description:  “KFC Server hotspot prediction between nsp10/16”
links:

 

https://mitchell-web.ornl.gov/KFC_Server/jmol.php?jobcode=24ab999b01540c1862c2fbd8f58f9da3
https://mitchell-web.ornl.gov/KFC_Server/jmol.php?jobcode=2c5e4a43972ba833dedc5415544266cc
https://mitchell-web.ornl.gov/KFC_Server/jmol.php?jobcode=70c16a08bf5fdfa2df745c1e8f87f6cf
https://mitchell-web.ornl.gov/KFC_Server/jmol.php?jobcode=28bc93ad87538b8628a48c463272f3f3

 

Description:  “Coronavirus-human protein-protein interaction map”
link: https://www.biorxiv.org/content/10.1101/2020.03.22.002386v3

 

Description:  “Bloomberg news reporting research in ORNL aimed at repurposing of existing drugs”
link: https://www.bloomberg.com/news/articles/2020-02-29/trump-team-testing-off-the-shelf-drugs-to-cure-coronavirus

 

Description:  “The Wall Street Journal article describing that computing power of supercomputers are concentrated on coronavirus projects”
link: https://www.wsj.com/articles/researchers-unleash-more-computing-power-against-coronavirus-11585566000

 

Description:  “Q13 Fox news reporting the project on Summit discovers compounds that may stop coronavirus from spreading”
link: https://q13fox.com/2020/03/19/the-worlds-fastest-supercomputer-identified-chemicals-that-could-stop-coronavirus-from-spreading-a-crucial-step-toward-a-vaccine/

 

Description:  “BBC Radio Norfolk clip of the interview of Dr. Jeremy Smith about using of Summit supercomputer in the current crisis”
link: https://www.bbc.co.uk/programmes/p087m1v2

 

Description:  “OneZero article describing using Summit supercomputer to screen drugs to treat coronavirus”
link: https://onezero.medium.com/the-worlds-most-powerful-supercomputer-has-entered-the-fight-against-coronavirus-3e98c4d67459

 

Description:  “Chattanooga Times Free Press article about the efforts in ORNL to combat coronavirus”
link: https://www.timesfreepress.com/news/opinion/times/story/2020/mar/13/sohn-tennessee-plays-big-role-hunt-covid-19/518087/

 

Description:  “Daily Memphian article reporting experimental screening of coronavirus drugs in University of Tennessee Health Science Center in Memphis”
link: https://dailymemphian.com/section/businesshealthcare/article/11360/dr-colleen-jonsson-uthsc

 

Description:  “WVLT video report about ONRL’s work to fight corona virus”
link: https://www.wvlt.tv/video?vid=568680752

 

Description:  “Rolling Stone article of interview of Dr. Jeremy Smith on coronavirus research”
link: https://www.rollingstone.com/culture/culture-news/molecular-biophysicists-search-cure-coronavirus-covid-19-965199/

 

Description:  “WBUR short radio clip about repurposing of drugs for coronavirus”
link: https://www.wbur.org/hereandnow/2020/03/23/supercomputers-covid-19-drugs

 

Description:  “Nextgov article about the contribution of Summit supercomputer in fighting against coronavirus”
link: https://www.nextgov.com/emerging-tech/2020/03/researchers-oak-ridge-national-lab-tap-supercomputing-help-combat-coronavirus/163708/

 

Description:  “Anchor clip about supercomputer’s role in coronavirus treatment”
link: https://anchor.fm/nextplatform/episodes/March-9–2020-Server-Market-Movements-Supercomputers-Role-in-Coronavirus-Treatment-The-Remote-World-ebag4i

 

Description:  “IEEE Spectrum article describing the drug screening projects on supercomputers”
link: https://spectrum.ieee.org/the-human-os/biomedical/devices/could-supercomputers-and-rapid-treatment-trials-slow-down-coronavirus

References:

1. Pi M et al., Mol Endocrinol. 2015, 29, 1759-1773.
2. Pi M et al., Endocrinology. 2016, 157, 1866-1880.
3. Evangelista W et al. Bioorg Med Chem. 2016, 24, 4928-4935.
4. Xiao Z et al. Sci Signal. 2016, 9, ra113.
5. Evangelista W et al. Bioorg Med Chem, 2016, 24, 4928-4935.
6. Abdali N et al. ACS Infect Dis. 2017, 3, 89-98.
7. Dale JB et al. Vaccine, 2017, 35, 19-26.
8. Haynes K et al. J Med Chem, 2017, 60, 6205-621.
9. Velazquez H et al. Chem Biol Drug Des. 2018, 91, 491–504.
10. Xiao Z et al. J Clin Invest, 2018, 128, 157-174.
11. Pi M. et al. PLoS ONE, 2018, 13, e0195980.
12. Darzynkiewicz Z et al. Biophys J, 2019, 116, 648-658.
13. Evangelista W et al. J Phys Chem, 2019, 123, 5189-5195.